One Large Kindred Excludes a Locus for Multiple Endocrine Neoplasia Type 2A from about 25% of the Human Autosomal Genetic Map

Authors

Andrew J. Pakstis
Judith R. Kidd
Carmela M. Castiglione
Beth A. Pletcher
Patricia D. Murphy
Lindsay A. Farrer
Myron Genel
Kenneth K. Kidd

Abstract

This report presents pairwise linkage results from our search for the locus of the gene (MEN2A) for the multiple endocrine neoplasia type 2A (MEN-2A) syndrome in one large kindred (the N kindred), clearly segregating for an autosomal dominant form. About 25% of the autosomal genome is excluded when these new results are combined with those we have published previously. The genetic markers employed are distributed across at least 19 of the 22 autosomes. Seven genetic markers whose chromosomal locations are not yet established have also been studied.

Recommended Citation

Pakstis, Andrew J.; Kidd, Judith R.; Castiglione, Carmela M.; Pletcher, Beth A.; Murphy, Patricia D.; Farrer, Lindsay A.; Genel, Myron; and Kidd, Kenneth K. (1987) "One Large Kindred Excludes a Locus for Multiple Endocrine Neoplasia Type 2A from about 25% of the Human Autosomal Genetic Map," Henry Ford Hospital Medical Journal : Vol. 35 : No. 2 , 164-167.
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol35/iss2/24