Symptoms and signs of pituitary disease are rarely the first manifestations of malignancy originating in another organ. We present a case which exemplifies the key points that suggest a diagnosis of metastatic pituitary disease. Our patient's diagnosis was adenocarcinoma of the lung with a metastasis to the intrasellar and suprasellar regions, which caused diabetes insipidus, anterior pituitary deficiency, and visual field defects. The metastasis had a dumbbell appearance and extended from the sella turcica into the suprasellar region. Diabetes insipidus was the initial clinical manifestation of lung cancer in this patient. A metastasis to the pituitary should be suspected if diabetes insipidus is the initial manifestation of an intrasellar mass.
Cryar, A. Keith; Morgan, Jay; Rock, Jack P.; and Wisgerhof, Max
"Pituitary Metastasis: Lung Cancer Presenting as Bitemporal Hemianopsia with Diabetes Insipidus and Anterior Pituitary Deficiency,"
Henry Ford Hospital Medical Journal
: Vol. 35
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol35/iss4/4