Enteric-coated fenoprofen was compared with standard fenoprofen (Nalfon, Dista, Indianapolis, IN) in a randomized, double-blind, parallel, three-month trial of 113 outpatients (mean age, 64 years) with large-joint osteoarthritis. A previous study showed that enteric coating of fenoprofen reduces gastrointestinal microbleeding and may offer a safety advantage. Both treatments provided statistically significant improvement in pain measures (tenderness on pressure, pain at rest, pain with weight-bearing activity, and pain on passive motion). Adverse experiences were similar with both treatments and of an expected type, severity, and incidence for nonsteroidal anti-inflammatory drugs. Enteric-coated fenoprofen was found to be as effective and safe as standard fenoprofen for large-joint osteoarthritis.
Bluhm, Gilbert B.; MacIlwain, Harris H.; and Offen, Walter W.
"Enteric-Coated Fenoprofen in Large-Joint Osteoarthritis,"
Henry Ford Hospital Medical Journal
: Vol. 36
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol36/iss1/15