Duplication and Deletion 11q23-q24 Recombinants in Two Offspring of an Intrachromosomal Insertion ("Shift") Carrier

Authors

Miriam G. Forsythe
Hugh Walker
Lester Weiss
Jacquelyn R. Roberson
Maria J. WorshamFollow
V. Ramesh BabuFollow
Daniel L. Van Dyke

Abstract

Few examples of intrachromosomal insertions have been described. These usually result from deletion of a segment of chromosome material, with insertion of the deleted material elsewhere on the same chromosome. Previous insertional translocations have been identified through a proband who has either a deletion or a duplication of the inserted segment. We describe a family which has two probands, one with a duplication and one with a deletion of the inserted segment. The unbalanced chromosomes probably resulted from an uneven number of crossovers between the breakpoints in the chromosome 11 of the father, who carries a balanced intrachromosomal insertion of the segment 11q23 .3-1 1q24.2 into the short arm of chromosome 11: 46,XY, ins(11)(p14.2q23.3q24.2).

Recommended Citation

Forsythe, Miriam G.; Walker, Hugh; Weiss, Lester; Roberson, Jacquelyn R.; Worsham, Maria J.; Babu, V. Ramesh; and Van Dyke, Daniel L. (1988) "Duplication and Deletion 11q23-q24 Recombinants in Two Offspring of an Intrachromosomal Insertion ("Shift") Carrier," Henry Ford Hospital Medical Journal : Vol. 36 : No. 4 , 183-186.
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol36/iss4/4