Few examples of intrachromosomal insertions have been described. These usually result from deletion of a segment of chromosome material, with insertion of the deleted material elsewhere on the same chromosome. Previous insertional translocations have been identified through a proband who has either a deletion or a duplication of the inserted segment. We describe a family which has two probands, one with a duplication and one with a deletion of the inserted segment. The unbalanced chromosomes probably resulted from an uneven number of crossovers between the breakpoints in the chromosome 11 of the father, who carries a balanced intrachromosomal insertion of the segment 11q23 .3-1 1q24.2 into the short arm of chromosome 11: 46,XY, ins(11)(p14.2q23.3q24.2).
Forsythe, Miriam G.; Walker, Hugh; Weiss, Lester; Roberson, Jacquelyn R.; Worsham, Maria J.; Babu, V. Ramesh; and Van Dyke, Daniel L.
"Duplication and Deletion 11q23-q24 Recombinants in Two Offspring of an Intrachromosomal Insertion ("Shift") Carrier,"
Henry Ford Hospital Medical Journal
: Vol. 36
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol36/iss4/4