Nineteen patients were surgically treated for hyperparathyroidism associated with multiple endocrine neoplasia type 1 syndrome. Fourteen patients (74%) had removal of three or more parathyroid glands at the first operation, and five (26%) by removal of 2 1/2 or fewer glands. Two patients had recurrent hypercalcemia during the mean follow-up period of 65 months. One had a recurrence 10 years after subtotal parathyroidectomy. Reexploration in this patient revealed enlargement of the remaining tissue in the neck and an enlarged supernumerary gland in the aorticopulmonary window. The other patient had persistent hypercalcemia after removal of two hyperplastic parathyroid glands until after another 1 1/2 more glands were removed. After reoperation the patient was normocalcemic for 10 years before hypercalcemia was again noticed. The patient subsequently died from renal carcinoma metastases, which might have been the cause of the hypercalcemia before death.
Obara, Takao; Fujimoto, Yoshihide; and Ito, Yukio
"Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1: Experience by a Single Surgical Team in Japan,"
Henry Ford Hospital Medical Journal
: Vol. 40
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol40/iss3/11