Pheochromocytoma is a frequent indicator of multiple endocrine neoplasia type 2A (MEN 2A); in the 35 French MEN 2A families in which a pheochromocytoma occurred first in some affected members, 30% of the patients had a pheochromocytoma as the first manifestation constituting 45% of all patients with pheochromocytomas. The finding of a pheochromocytoma is a strong indication for a search for medullary thyroid carcinoma and for initiating family screening.
Calmettes, Claude; Rosenberg-Gourgin, Myriam; Caron, Jean; and Feingold, Nicole
"Pheochromocytoma: A Frequent Indicator for MEN 2,"
Henry Ford Hospital Medical Journal
: Vol. 40
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol40/iss3/31