Patterns of Neoplasia in c-Mos Transgenic Mice and Their Relevance to Multiple Endocrine Neoplasia

Authors

Nicholas Schulz
Friedrich Propst
Michael M. Rosenberg
R. Ilona Linnoila
Richard S. Paules
Douglas Schulte
George F. Vande Woude

Abstract

We have previously described a neurological phenotype for transgenic mice carrying the c-Mos proto-oncogene. Pheochromocytomas and C-cell thyroid neoplasms occur in these transgenic lines in patterns that are similar to those seen in multiple endocrine neoplasia type 2 (MEN 2). Characterization of the pathological lesions via immunohistochemistry underscores similarities between MEN 2 and these transgenic mice. When transgenic mice that do not display the MEN 2 phenotype are crossed to a different background, the progeny display the MEN 2 phenotype. Thus the interaction of the background with the transgene is such that it can suppress tumor information. This observation bears special relevance to the human syndrome in that this model system may be used to study the question of penetrance of phenotype.

Recommended Citation

Schulz, Nicholas; Propst, Friedrich; Rosenberg, Michael M.; Linnoila, R. Ilona; Paules, Richard S.; Schulte, Douglas; and Vande Woude, George F. (1992) "Patterns of Neoplasia in c-Mos Transgenic Mice and Their Relevance to Multiple Endocrine Neoplasia," Henry Ford Hospital Medical Journal : Vol. 40 : No. 3 , 307-311.
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol40/iss3/40