Practical Guidelines for DNA-Based Testing in Multiple Endocrine Neoplasia Type 1

Authors

Catharina Larsson
Magnus Nordenskjold
Britt Skogseid
Kjell Oberg

Abstract

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant predisposition to neoplastic lesions of the parathyroid glands, the neuroendocrine pancreas, and the anterior pituitary gland. The predisposing genetic defect was localized to the long arm of chromosome 11 by genetic linkage analysis in three affected families. By analyzing six MEN 1 families with 14 DNA marker systems located close to the MEN 1 gene, we have developed a method to identify carriers of the MEN 1 predisposition. We describe practical aspects of such DNA-based diagnostic procedures.

Recommended Citation

Larsson, Catharina; Nordenskjold, Magnus; Skogseid, Britt; and Oberg, Kjell (1992) "Practical Guidelines for DNA-Based Testing in Multiple Endocrine Neoplasia Type 1," Henry Ford Hospital Medical Journal : Vol. 40 : No. 3 , 173-176.
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol40/iss3/7