Exercise, Prostaglandin E(2), and Cardiometabolic Health: From Molecular Signaling to Systemic Adaptation

Authors

• Joseph T. Mannozzi, Henry Ford HealthFollow
• Mike M. Ravn Pedersen, Henry Ford Health
• Shaheen Y. Bhat, Henry Ford HealthFollow
• Timothy D. Bryson, Henry Ford HealthFollow

Recommended Citation

Mannozzi J, Ravn Pedersen MM, Bhat SY, Bryson TD. Exercise, Prostaglandin E(2), and Cardiometabolic Health: From Molecular Signaling to Systemic Adaptation. Cells. 2026;15(14).

Document Type

Article

Publication Date

7-12-2026

Publication Title

Cells

Keywords

Humans, Dinoprostone, Signal Transduction, Animals, Exercise, Adaptation, Physiological

Abstract

Exercise is a cost-effective cornerstone therapy available to all for the treatment of cardiometabolic disorders, yet the molecular mediators linking physical activity to systemic metabolic and cardiovascular adaptations remain incompletely defined. Prostaglandin E(2) (PGE(2)) is a bioactive lipid derived from arachidonic acid metabolism and has recently emerged as a critical regulator of inflammation, vascular function, mitochondrial remodeling, and glucose-lipid homeostasis. This review synthesizes current evidence on PGE(2) biosynthesis and signaling in the context of exercise, with a focus on its broader role in cardiometabolic health and disease.

Medical Subject Headings

Humans; Dinoprostone; Signal Transduction; Animals; Exercise; Adaptation, Physiological

PubMed ID

42505364

Volume

15

Issue

14