Title

Mechanisms of connecting tubule glomerular feedback enhancement by aldosterone

Authors

Yilin Ren, Henry Ford HealthFollow
Brana Janic, Henry Ford HealthFollow
Kristopher Kutskill
Edward L. Peterson, Henry Ford HealthFollow
Oscar A. Carretero, Henry Ford HealthFollow

Recommended Citation

Ren Y, Janic B, Kutskill K, Peterson EL, Carretero OA. Mechanisms of connecting tubule glomerular feedback enhancement by aldosterone. Am J Physiol Renal Physiol. Jul 13 2016:ajprenal.00076.02016.

Document Type

Article

Publication Date

12-1-2016

Publication Title

American journal of physiology. Renal physiology

Abstract

Connecting tubule glomerular feedback (CTGF) is a mechanism where an increase in sodium (Na) concentration in the connecting tubule (CNT) causes the afferent arteriole (Af-Art) to dilate. We recently reported that aldosterone within the CNT lumen enhances CTGF via a nongenomic effect involving GPR30 receptors and sodium/hydrogen exchanger (NHE), but the signaling pathways of this mechanism are unknown. We hypothesize that aldosterone enhances CTGF via cAMP/protein kinase A (PKA) pathway that activates protein kinase C (PKC) and stimulates superoxide (O

Medical Subject Headings

Aldosterone; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic N-Oxides; Dose-Response Relationship, Drug; Feedback, Physiological; Isoquinolines; Kidney Glomerulus; Male; Protein Kinase C; Rabbits; Signal Transduction; Sodium Chloride; Spin Labels; Sulfonamides

PubMed ID

27413197

Volume

311

Issue

6

First Page

1182

Last Page

1182