ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes
Recommended Citation
Pan G, Deshpande M, Thandavarayan RA, Palaniyandi SS. ALDH2 Inhibition potentiates high glucose stress-induced injury in cultured cardiomyocytes. J Diabetes Res. 2016;2016:1390861.
Document Type
Article
Publication Date
1-1-2016
Publication Title
J Diabetes Res
Abstract
Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde produced upon lipid peroxidation in diabetic conditions. We hypothesized that inhibition of ALDH leads to the accumulation of unmetabolized 4HNE and consequently exacerbates injury in cells subjected to high glucose stress. H9C2 cardiomyocyte cell lines were pretreated with 10
Medical Subject Headings
Acetaldehyde Dehydrogenase Inhibitors; Aldehyde Dehydrogenase, Mitochondrial; Cell Line; Disulfiram; Glucose; Humans; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Osmotic Pressure; Reactive Oxygen Species
PubMed ID
27882330
Volume
2016
First Page
1390861
Last Page
1390861
