Title

ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes

Authors

Guodong Pan, Henry Ford HealthFollow
Mandar Deshpande, Henry Ford HealthFollow
Rajarajan A. Thandavarayan
Suresh S. Palaniyandi, Henry Ford HealthFollow

Recommended Citation

Pan G, Deshpande M, Thandavarayan RA, Palaniyandi SS. ALDH2 Inhibition potentiates high glucose stress-induced injury in cultured cardiomyocytes. J Diabetes Res. 2016;2016:1390861.

Document Type

Article

Publication Date

1-1-2016

Publication Title

J Diabetes Res

Abstract

Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde produced upon lipid peroxidation in diabetic conditions. We hypothesized that inhibition of ALDH leads to the accumulation of unmetabolized 4HNE and consequently exacerbates injury in cells subjected to high glucose stress. H9C2 cardiomyocyte cell lines were pretreated with 10

Medical Subject Headings

Acetaldehyde Dehydrogenase Inhibitors; Aldehyde Dehydrogenase, Mitochondrial; Cell Line; Disulfiram; Glucose; Humans; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Osmotic Pressure; Reactive Oxygen Species

PubMed ID

27882330

Volume

2016

First Page

1390861

Last Page

1390861