Title

Prostaglandin E2 EP receptors in cardiovascular disease: An update

Authors

Timothy D Bryson
Pamela Harding, Henry Ford HealthFollow

Recommended Citation

Bryson TD, and Harding P. Prostaglandin E2 EP receptors in cardiovascular disease: An update. Biochem Pharmacol 2021; 195:114858.

Document Type

Article

Publication Date

11-22-2021

Publication Title

Biochemical pharmacology

Abstract

This review article provides an update for the role of prostaglandin E2 receptors (EP1, EP2, EP3 and EP4) in cardiovascular disease. Where possible we have reported citations from the last decade although this was not possible for all of the topics covered due to the paucity of publications. The authors have attempted to cover the subjects of ischemia-reperfusion injury, arrhythmias, hypertension, novel protein binding partners of the EP receptors and their pathophysiological significance, and cardiac regeneration. These latter two topics bring studies of the EP receptors into new and exciting areas of research that are just beginning to be explored. Where there is peer-reviewed literature, the authors have placed particular emphasis on clinical studies although these are limited in number.

PubMed ID

34822808

Volume

195

First Page

114858

Last Page

114858