Decreased aldehyde dehydrogenase (aldh)2 activity contributes to coronary endothelial dysfunction in diabetic cardiomyopathy

Document Type

Conference Proceeding

Publication Date

2017

Publication Title

J Mol Cell Cardiol

Abstract

Background: Around 8% of Americans acquire diabetes mellitus (DM). Diabetics cause micro and macrovascular complications to develop, that lead to end-organ damage. However, microvascular damage is understudied in diabetic cardiomyopathy (DCM), despite needing extensive coronary perfusion. Hyperglycemia-mediated reactive aldehydes, like 4-hydroxy-2-nonenal (4HNE) are associated with cardiac damage. Aldehyde dehydrogenase (ALDH) 2, a mitochondrial enzyme which detoxifies 4HNE, is implicated in endothelial cell function in vasculature.

Volume

112

First Page

135

Last Page

136

This document is currently not available here.

Share

COinS