Decreased aldehyde dehydrogenase (aldh)2 activity contributes to coronary endothelial dysfunction in diabetic cardiomyopathy

Authors

Guodong Pan, Henry Ford HealthFollow
Mandar Deshpande, Henry Ford HealthFollow
Suresh S. Palaniyandi, Henry Ford HealthFollow

Recommended Citation

Pan GD, Deshpande M, and Palaniyandi SS. Decreased aldehyde dehydrogenase (aldh)2 activity contributes to coronary endothelial dysfunction in diabetic cardiomyopathy. J Mol Cell Cardiol 2017; 112:135-136.

Document Type

Conference Proceeding

Publication Date

2017

Publication Title

J Mol Cell Cardiol

Abstract

Background: Around 8% of Americans acquire diabetes mellitus (DM). Diabetics cause micro and macrovascular complications to develop, that lead to end-organ damage. However, microvascular damage is understudied in diabetic cardiomyopathy (DCM), despite needing extensive coronary perfusion. Hyperglycemia-mediated reactive aldehydes, like 4-hydroxy-2-nonenal (4HNE) are associated with cardiac damage. Aldehyde dehydrogenase (ALDH) 2, a mitochondrial enzyme which detoxifies 4HNE, is implicated in endothelial cell function in vasculature.

Volume

112

First Page

135

Last Page

136