Decreased aldehyde dehydrogenase (aldh)2 activity contributes to coronary endothelial dysfunction in diabetic cardiomyopathy
Pan GD, Deshpande M, and Palaniyandi SS. Decreased aldehyde dehydrogenase (aldh)2 activity contributes to coronary endothelial dysfunction in diabetic cardiomyopathy. J Mol Cell Cardiol 2017; 112:135-136.
J Mol Cell Cardiol
Background: Around 8% of Americans acquire diabetes mellitus (DM). Diabetics cause micro and macrovascular complications to develop, that lead to end-organ damage. However, microvascular damage is understudied in diabetic cardiomyopathy (DCM), despite needing extensive coronary perfusion. Hyperglycemia-mediated reactive aldehydes, like 4-hydroxy-2-nonenal (4HNE) are associated with cardiac damage. Aldehyde dehydrogenase (ALDH) 2, a mitochondrial enzyme which detoxifies 4HNE, is implicated in endothelial cell function in vasculature.