Document Type

Article

Publication Date

6-16-2023

Publication Title

BMJ Open

Abstract

OBJECTIVE: We studied the safety and efficacy of hydroxychloroquine (HCQ) as pre-exposure prophylaxis for COVID-19 in healthcare workers (HCWs), using a meta-analysis of randomised controlled trials (RCTs).

DATA SOURCES: PubMed and EMBASE databases were searched to identify randomised trials studying HCQ.

STUDY SELECTION: Ten RCTs were identified (n=5079 participants).

DATA EXTRACTION AND SYNTHESIS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used in this systematic review and meta-analysis between HCQ and placebo using a Bayesian random-effects model. A pre-hoc statistical analysis plan was written.

MAIN OUTCOMES: The primary efficacy outcome was PCR-confirmed SARS-CoV-2 infection and the primary safety outcome was incidence of adverse events. The secondary outcome included clinically suspected SARS-CoV-2 infection.

RESULTS: Compared with placebo, HCWs randomised to HCQ had no significant difference in PCR-confirmed SARS-CoV-2 infection (OR 0.92, 95% credible interval (CI): 0.58, 1.37) or clinically suspected SARS-CoV-2 infection (OR 0.78, 95% CI: 0.57, 1.10), but significant difference in adverse events (OR 1.35, 95% CI: 1.03, 1.73).

CONCLUSIONS AND RELEVANCE: Our meta-analysis of 10 RCTs investigating the safety and efficacy of HCQ as pre-exposure prophylaxis in HCWs found that compared with placebo, HCQ does not significantly reduce the risk of confirmed or clinically suspected SARS-CoV-2 infection, while HCQ significantly increases adverse events.

PROSPERO REGISTRATION NUMBER: CRD42021285093.

Medical Subject Headings

Humans; COVID-19; COVID-19 Drug Treatment; Health Personnel; Hydroxychloroquine; SARS-CoV-2; Pre-Exposure Prophylaxis

PubMed ID

37328184

Volume

13

Issue

6

First Page

065305

Last Page

065305

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