Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru

Document Type

Article

Publication Date

11-1-2023

Publication Title

The American journal of tropical medicine and hygiene

Abstract

There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017-2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non-Panton-Valentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)-SCCmec IV, PVL-producer-(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.

Medical Subject Headings

Humans; Methicillin-Resistant Staphylococcus aureus; Staphylococcus aureus; Peru; Staphylococcal Infections; Community-Acquired Infections; Exotoxins; Leukocidins; Sepsis; Microbial Sensitivity Tests; Anti-Bacterial Agents

PubMed ID

37722664

ePublication

ePub ahead of print

Volume

109

Issue

5

First Page

1118

Last Page

1121

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