Autoimmune disease and vaccination: impact on infectious disease prevention and a look at future applications

Document Type

Article

Publication Date

1-1-2016

Publication Title

Transl Res

Abstract

Vaccines hold promise both for the prevention of infections and as potential immunologic therapy for patients with autoimmune disease (AD). These patients are at high risk for both common and opportunistic infections, but this risk can be significantly reduced and even obviated with the use of recommended available vaccines. Unfortunately, patients with ADs are not routinely offered or provided indicated vaccinations and have higher rates of complications from vaccine-preventable illnesses than patients without ADs. In addition, vaccine therapy is currently under study for the treatment of autoimmune disorders, with early studies demonstrating immunomodulatory effects that may counter undesired immune activation and alleviate disease activity.

Medical Subject Headings

Autoimmune Diseases; Communicable Diseases; Humans; Immunocompromised Host; Immunotherapy; Vaccination

PubMed ID

26408802

Volume

167

Issue

1

First Page

46

Last Page

60

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