Chronic resveratrol reverses a mild angiotensin II-induced pressor effect in a rat model

Document Type

Article

Publication Date

1-1-2016

Publication Title

Integr Blood Press Control

Abstract

Resveratrol is reported to reduce blood pressure in animal models of hypertension, but the mechanisms are unknown. We have shown that resveratrol infusion increases sodium excretion. We hypothesized that chronic ingestion of resveratrol would reduce angiotensin II (Ang II)-induced increases in blood pressure by decreasing oxidative stress and by also decreasing sodium reabsorption through a nitric oxide-dependent mechanism. We infused rats with vehicle or 80 μg Ang II/d over 4 weeks. Vehicle or Ang II-infused rats were individually housed, pair fed, and placed on a diet of normal chow or normal chow plus 146 mg resveratrol/d. Groups included 1) control, 2) resveratrol-fed, 3) Ang II-treated, and 4) Ang II plus resveratrol. Systolic blood pressure was measured by tail cuff. During the 4th week, rats were placed in metabolic caging for urine collection. NO2/NO3 and 8-isoprostane excretion were measured. Ang II increased systolic blood pressure in the 1st week by +14±5 mmHg (P

Comments

First published by Dove Medical Press. Original version available at: https://doi.org/10.2147/IBPC.S96092. Creative Commons Attribution Non-Commercial License

PubMed ID

26869812

Volume

9

First Page

23

Last Page

31

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