Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers
Recommended Citation
Liu Q, Wu DH, Han L, Deng JW, Zhou L, He R, Lu CJ, Mi QS. Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers. Exp Dermatol. 2017 Apr;26(4):359-367.
Document Type
Article
Publication Date
4-1-2017
Publication Title
Experimental dermatology
Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNAs in psoriasis and showed that miRNAs play key roles in psoriasis, including the regulation of hyperproliferation, cytokine and chemokine production in keratinocyte, as well as mediating immune dysfunction in psoriasis. Furthermore, miRNAs, particularly, circulating miRNAs may serve as novel biomarkers for diagnosis, monitoring therapy response and reflecting the disease severity. Thus, targeting specific miRNAs may be used to develop new therapeutic methods for psoriasis.
Medical Subject Headings
Biomarkers; Cell Proliferation; Humans; Immunity, Cellular; Keratinocytes; MicroRNAs; Molecular Targeted Therapy; Psoriasis; Severity of Illness Index
PubMed ID
27783430
Volume
26
Issue
4
First Page
359
Last Page
367
