Gastroparesis: an under-recognised manifestation of systemic amyloidosis
Recommended Citation
Abdullah KM, Alsuraimi A, Kagbo-Kue S, and Vela M. Gastroparesis: an under-recognised manifestation of systemic amyloidosis. BMJ Case Rep 2023; 16(5).
Document Type
Article
Publication Date
5-2-2023
Publication Title
BMJ Case Rep
Abstract
Gastrointestinal (GI) amyloidosis can be acquired or genetic and is commonly caused by chronic inflammatory illnesses (AA amyloidosis), haematological malignancies (AL amyloidosis) and end-stage renal disease (beta-2 microglobulin amyloidosis). The accumulation of these aberrant proteins disrupts the structures and functions of many organs; the least common of which is the GI tract. GI presentations depend on the type, location and amount of amyloid deposition. Symptoms can range from nausea and vomiting to fatal GI bleeds. Pathological examination of the involved tissue with characteristic green birefringence under polarised light is used to confirm the diagnosis. Patients should be considered for further evaluation to rule out additional organ involvement, notably cardiac and renal. We present a patient with amyloidosis-induced gastroparesis, an under-recognised presentation of systemic amyloidosis in the gastroenterology system.
Medical Subject Headings
Humans; Immunoglobulin Light-chain Amyloidosis; Gastroparesis; Amyloidosis; Gastrointestinal Hemorrhage
PubMed ID
37130641
Volume
16
Issue
5
