Efficacy and Safety of Linaclotide as an Adjunct to Polyethylene Glycol in Bowel Preparation: A Meta-Analysis
Recommended Citation
Shahzil M, Hasan F, Qureshi AA, Jamil Z, Kashif T, Faisal MS, Arif TB, Chaudhary AJ, Farooq U, Ali H, and Levenick JM. Efficacy and Safety of Linaclotide as an Adjunct to Polyethylene Glycol in Bowel Preparation: A Meta-Analysis. J Dig Dis 2025;28(7-8):318-333.
Document Type
Article
Publication Date
9-16-2025
Publication Title
J Dig Dis
Abstract
OBJECTIVES: Linaclotide, a guanylyl cyclase-C agonist, may enhance efficacy and tolerability when combined with polyethylene glycol (PEG) for bowel preparation. This meta-analysis evaluated linaclotide plus PEG versus PEG alone for bowel preparation prior to colonoscopy.
METHODS: Randomized controlled trials (RCTs) including adults undergoing colonoscopy that compared linaclotide plus PEG with PEG alone for bowel preparation were identified via database search up to March 2024. Statistical analysis was performed in RevMan Web using random-effects models.
RESULTS: Eleven RCTs were analyzed. Adequate bowel preparation rate was comparable (risk ratio [RR] 1.01, 95% confidence interval [CI] 0.98-1.04; I(2) = 23%), as was cecal intubation rate (RR 1.01, 95% CI 1.00-1.01). Subgroup analyses showed that compared with 3-L PEG alone, 2-L PEG plus linaclotide was non-inferior, while 3-L PEG plus linaclotide was superior regarding bowel preparation adequacy (RR 1.11, 95% CI 1.01-1.23) and total Boston Bowel Preparation Scale (BBPS) score (mean difference 0.44, 95% CI 0.04-0.85). Right and left colon BBPS scores were also higher with linaclotide. Polyp detection rate improved significantly in the 3-L PEG plus linaclotide subgroup (RR 1.78, 95% CI 1.32-2.40), whereas adenoma detection rate and withdrawal time were comparable. Linaclotide reduced abdominal pain, bloating, nausea, and sleep disturbance, and increased willingness to repeat colonoscopy.
CONCLUSIONS: Linaclotide with PEG provides comparable overall bowel cleansing to PEG alone while reducing adverse events and improving patient acceptance. Importantly, 2-L PEG plus linaclotide was non-inferior compared with 3-L PEG, whereas 3-L PEG plus linaclotide showed superiority over 3-L PEG alone, supporting its use in low-volume bowel preparation strategies.
Medical Subject Headings
Humans; Polyethylene Glycols; Colonoscopy; Peptides; Cathartics; Randomized Controlled Trials as Topic; Guanylyl Cyclase C Agonists; Male
PubMed ID
40955723
ePublication
ePub ahead of print
Volume
26
Issue
7-8
First Page
318
Last Page
333
