Coronary artery disease in patients undergoing transcatheter aortic valve replacement: Current evidence and future directions
Recommended Citation
Wehbeh BED, Al Sakan M, Francis J, Ghazal R, Alam S, Sawaya F. Coronary artery disease in patients undergoing transcatheter aortic valve replacement: Current evidence and future directions. Am Heart J Plus. 2026;62:100710.
Document Type
Article
Publication Date
2-1-2026
Publication Title
Am Heart J Plus
Keywords
Aortic valve implantation; Coronary artery disease; Transcatheter aortic valve replacement
Abstract
Coronary artery disease (CAD) coexists frequently with aortic stenosis (AS), and the optimal management of CAD in patients undergoing transcatheter aortic valve replacement (TAVR) remains incompletely defined due to limited and heterogeneous evidence. This review aims to integrate the current evidence on the epidemiology and shared pathophysiology of CAD and AS, summarize the diagnostic algorithms for CAD in the TAVR population, and evaluates revascularization strategies with a focus on the timing of percutaneous coronary intervention relative to valve replacement. Current evidence suggests that while routine PCI in TAVR candidates for stable CAD may offer limited benefit, revascularization in patients with complex CAD or high anatomical burden may improve outcomes. This review further characterizes the incidence, proposed mechanisms, and prognostic significance of post-TAVR coronary events and outlines emerging strategies to optimize ischemic and procedural outcomes in this high-risk cohort.
PubMed ID
41561402
Volume
62
First Page
100710
Last Page
100710
