A Common Medication With a Rare Side Effect: A Case Report of Statin-Induced Necrotizing Autoimmune Myopathy

Document Type

Article

Publication Date

5-1-2025

Publication Title

Cureus

Keywords

adverse drug reaction; anti-hmg-coa reductase antibody; anti-signal recognition particle antibody; myopathy; statin-induced necrotizing autoimmune myopathy; statins

Abstract

Statins are commonly used for their cholesterol-lowering properties and are prescribed for primary and secondary prevention of cardiovascular disease. Although they are generally well tolerated, some individuals may experience a rare and serious side effect in which autoantibodies develop and lead to a necrotizing myopathy. Here we present a case of a middle-aged woman chronically on atorvastatin for her hyperlipidemia who acutely developed myalgias, muscle weakness, and persistently elevated creatine kinase, who was eventually diagnosed with statin-induced necrotizing autoimmune myopathy.

PubMed ID

40476112

Volume

17

Issue

5

First Page

83589

Last Page

83589

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