Sex, Not Age, Predicts Weight Loss Outcomes With Tirzepatide: A Retrospective Analysis

Document Type

Article

Publication Date

9-1-2026

Publication Title

Obesity (Silver Spring)

Keywords

Humans, Tirzepatide, Retrospective Studies, Female, Weight Loss, Obesity, Male, Middle Aged, Sex Factors, Age Factors, Treatment Outcome, Anti-Obesity Agents, Aged, Overweight, Adult

Abstract

OBJECTIVE: This study assessed the impact of sex and age on weight loss outcomes in patients receiving tirzepatide in real-world clinical practice.

METHODS: We conducted a retrospective cohort study of adults with overweight or obesity who initiated tirzepatide at Mayo Clinic between June 2022 and May 2024 and completed ≥ 12 months of continuous therapy. Primary outcome was total body weight loss percentage (TBWL%) at 15 months, stratified by sex and age groups (≤ 45, 46-59, ≥ 60 years).

RESULTS: Among 1039 patients (57% women; mean age 56 ± 11 years), women achieved significantly greater TBWL% than men after 15 months of treatment (15.1% vs. 10.7%, p <  0.001). Patients aged ≤ 45 years had greater weight loss than those ≥ 60 years (15.1% vs. 12.3%, p = 0.024). In multivariable analyses, greater weight loss was independently associated with female sex, absence of type 2 diabetes, no prior obesity medication use, no concomitant weight gain-promoting medications, and higher tirzepatide dosage. Age was not an independent predictor.

CONCLUSIONS: Sex, but not age, predicted weight loss with tirzepatide among individuals using the medication continuously for ≥ 12 months. These findings underscore the importance of incorporating sex-specific considerations into personalized obesity treatment strategies.

Medical Subject Headings

Humans; Tirzepatide; Retrospective Studies; Female; Weight Loss; Obesity; Male; Middle Aged; Sex Factors; Age Factors; Treatment Outcome; Anti-Obesity Agents; Aged; Overweight; Adult

PubMed ID

42290037

Volume

34

Issue

Suppl 2

First Page

132

Last Page

145

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