Impact of Prolonged PR Interval on Recurrence of Atrial Fibrillation after Catheter Ablation: A Systematic Review and Meta-analysis with Reconstructed Time-to-Event Data
Recommended Citation
Amin AM, Manasrah A, Modi K, Khassawneh AM. Impact of Prolonged PR Interval on Recurrence of Atrial Fibrillation after Catheter Ablation: A Systematic Review and Meta-analysis with Reconstructed Time-to-Event Data. Circulation 2024; 150(Suppl 1).
Document Type
Conference Proceeding
Publication Date
11-11-2024
Publication Title
Circulation
Keywords
biological marker, atrial fibrillation, catheter ablation, conference abstract, coronary artery disease, electrocardiography, follow up, heart atrium remodeling, heart failure, human, incidence, meta analysis, pacemaker implantation, PR interval, recurrent disease, systematic review
Abstract
Background: A prolonged PR interval has been demonstrated as a predictor of increased risk for incident atrial fibrillation (AF), coronary artery disease, heart failure, and pacemaker implantation. Purpose: We aim to investigate the impact of prolonged PR interval > 200 ms on AF recurrence after catheter ablation. Methods: We comprehensively searched PubMed, WOS, SCOPUS, EMBASE, and CENTRAL through May 2024. We conducted a pair-wise and prognostic systematic review and meta-analysis with a reconstructed time-to-event data meta-analysis. All analyses were performed using R V. 4.3.1. Results: With the inclusion of four studies, our cohort comprised a total of 2,790 patients. Regarding pair-wise meta-analysis, PR interval > 200 ms was significantly associated with an increased incidence of AF recurrence compared to PR interval ≤ 200 ms (RR: 1.50 with 95% CI [1.33, 1.70], P< 0.01). Regarding adjusted prognostic meta-analysis, PR interval > 200 ms was significantly associated with a 92% increase in the risk of AF recurrence compared to PR interval ≤ 200 ms (HR: 1.92 with 95% CI [1.61, 2.30], P< 0.01). Our reconstructed Kaplan Meier showed that a PR interval > 200 ms was significantly associated with a 65% increase in the risk of AF recurrence compared to a PR interval ≤ 200 ms (HR: 1.65 with 95% CI [1.42, 1.92], P< 0.00001) over 120 months follow-up. Conclusion: Our meta-analysis concluded that a prolonged PR interval greater than 200 ms is a significant predictor of AF recurrence after catheter ablation, reflecting atrial remodeling, and since the PR interval can be easily measured by a surface 12-lead ECG, patients with a prolonged PR interval may require additional treatment strategies.
Volume
150
Issue
Suppl 1
