SEPSIS-RELATED MORTALITY RATES AND TRENDS BASED ON THE CAUSATIVE ORGANISM

Document Type

Conference Proceeding

Publication Date

1-1-2025

Publication Title

Crit Care Med

Keywords

adult, African American, aged, ancestry group, Asian, cadaver, Caucasian, cause of death, cohort analysis, conference abstract, epidemiology, female, gender, human, major clinical study, male, mortality rate, prevalence, race, retrospective study, sepsis, Staphylococcus aureus, Streptococcus, United States

Abstract

INTRODUCTION: Sepsis is the third leading cause of mortality in the United States and affects nearly 1.7 million adults every year. Previous studies have shown an increasing prevalence of sepsis but stable sepsis-related mortality rates. Until now, sepsis-related mortality rates and trends stratified by the inciting organism have not been evaluated. This study evaluates the epidemiology of sepsis from the most common types of bacteria. METHODS: We describe a retrospective populationbased study where we obtained age-adjusted mortality rate data with sepsis from Staphylococcus aureus (S. aureus), Streptococcus, and gram-negative bacteria as the principal diagnosis from 1999 to 2020. The data was extracted through the Multiple Causes of Death (MCOD) database available through the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER), and joinpoint regression analysis was performed. We selected decedents with sepsisrelated deaths, and the organism associated was identified using previously validated International Classification of Diseases codes. RESULTS: From 1999 to 2020, using the MCOD, the age-adjusted mortality rate per 1,000,000 population from sepsis from S. aureus declined from 18.56 to 6.6, Streptococcus from 8.26 to 3.53, and gram-negatives from 14.04 to 8.93. The average annual percentage change for S. aureus, Streptococcus, and gram-negative, was -5.37% (p< 0.001), -4.04% (p< 0.001), and -2.38% (p< 0.001), respectively. Across all the organism groups, males had a higher mortality rate than females. Black or African-American race had a higher mortality rate, followed by White and Asian descendants across all three groups. CONCLUSIONS: The rate of sepsis-related mortality rates has decreased considerably over the last two decades, in part from the Surviving Sepsis Campaign leading to better identification and treatment strategies. However, we note significant variation based on gender and racial groups, which should be considered in future studies.

Volume

53

Issue

1

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