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Rare Histological Variants of Prostate Adenocarcinoma (PCa): NCDB Analysis
Sohrab Arora, Chandler Bronkema, Akshay Sood, Deepansh Dalela, Jacob Keeley, Mani Menon, and Firas Abdollah
Introduction and Objective: American Joint Committee on Cancer (AJCC) recognizes five rare histological variants of prostate adenocarcinoma (PCa). Our aim was to describe the contemporary presentation and overall survival (OS) of these rare variants. Methods: From 2004-2015, we selected cases of mucinous, ductal, signet ring cell (SRC), Adenosquamous, and neuroendocrine (NEC) variants of PCa from the National Cancer Database. Characteristics at presentation for each variant were compared with nonvariant... Read More
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Increasing Incidence of MDROs: An Emerging Global Concern
Zohra Chaudhry, Hind Hadid, Mary B. Perri, Marcus J. Zervos, and Indira Brar
Introduction: With massive efflux of civilians from violence-stricken countries, the high rates of colonization with multidrug-resistant organisms (MDROs) amongst the refugees is an emerging global concern. Our report describes two Middle Eastern patients who suffered severe traumatic injuries in their home countries, subsequently developing chronic wounds. Upon arrival to the United States, the patients sought treatment in our institution for wound infection with MDRO. Materials and methods: Clinical data... Read More
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Gleason Grade Group Prediction for Prostate Cancer Patients with MR Images Using Convolutional Neural Network
Joon K. Lee, WeiWei Zong, Milan Pantelic, and Ning Wen
Purpose: Gleason Grading (GG) Grouping system is an important index in determining treatment plan or predicting outcome for prostate cancer patients. Unfortunately, currently GG Grouping results can only be obtained from biopsy-driven pathological tests. We aim to predict GG groups for PCa patients from multiparametric magnetic resonance images (mp-MRI). Methods: The challenges include data heterogeneity, small sample size and highly imbalanced distribution among different groups. A retrospective collection of... Read More
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Pathological Staging of Renal Cell Carcinoma: A Review of 300 Consecutive Cases
Kanika Taneja, Sohrab Arora, Nilesh S. Gupta, Craig G. Rogers, and Sean R. Williamson
Aims: Pathological staging of renal cell carcinoma (RCC) can be challenging compared to other cancer types, as invasion often manifests as finger‐like protrusions into vascular spaces or renal sinus tissue. Although prior studies have shown larger tumour size to be correlated highly with renal sinus invasion, prospective data on evaluating pathological stage are limited. We evaluated a large series reported by one urological pathologist. Methods and results: Three hundred... Read More
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Should Patients on Metformin Be Screened for Vit B12 Deficiency, and if so When?
Jeet Thaker, Darby Martin, Pooja Kulkarni, Rehab Bakir, Diahann Marshal, Berta Rezik, Islam Zin El Din, Andrea Smith, Lois Lamerato, and Katarzyna Budzynska
Background: Metformin and its ability to cause vitamin B12 deficiency has been thoroughly studied and documented. Despite this, there is no formal screening recommendation. Our study investigates: whether there is a benefit to a formal screening guideline and, if so, when is it appropriate to screen for vitamin B12 deficiency in patients on Metformin. We additionally investigated quantifying if vitamin B12 testing is completed.Methods:We conducted a retrospective cohort study... Read More
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