Is Remote Ischemic Conditioning of Benefit to Patients Undergoing Kidney Transplantation?

Document Type

Article

Publication Date

1-1-2019

Publication Title

Journal of investigative surgery : the official journal of the Academy of Surgical Research

Abstract

Renal ischemia-reperfusion injury (IRI), an inevitable event during kidney transplantation procedure, can result in delayed graft function or even primary nonfunction. In addition to strategies to limit IRI such as advancements in organ allocation systems and preservation of organs, and reduction in cold and warm ischemia time, remote ischemic conditioning (RIC) has attracted much attention in recent years. With promising findings and data suggesting a potential benefit of RIC in animal kidney transplantation models, a few clinical trials have investigated the use of RIC in human kidney transplantation. Unfortunately, the findings from these investigations have been inconclusive due to a number of factors such as diverse time points of RIC, limited sample size, and complexity of kidney transplant patients. This brief commentary aims to discuss the effects of RIC on clinical outcomes and proinflammatory cytokines in patients undergoing kidney transplantation.

PubMed ID

29023177

Volume

32

Issue

1

First Page

72

Last Page

74

Find It @ Sladen

Share

COinS