Recommended Citation
Soi V, and Yee J. Sodium homeostasis in chronic kidney disease. Adv Chronic Kidney Dis 2017; 24(5):325-331.
Document Type
Article
Publication Date
9-1-2017
Publication Title
Advances in chronic kidney disease
Abstract
The pathologic consequences of sodium retention in the CKD population can lead to hypertension, edema, and progressive disease. Sodium excess is responsible for increases in oxidative stress, which alters kidney vasculature. As progression of CKD occurs, hyperfiltration by remaining nephrons compensates for an overall decrease in the filtered load of sodium. In the later stages of CKD, compensatory mechanisms are overcome and volume overload ensues. Nephrotic syndrome as it relates to sodium handling involves a different pathophysiology despite a common phenotype. Extrarenal sodium buffering is also examined as it has significant implications in the setting of advanced CKD.
Medical Subject Headings
Animals; Atrial Natriuretic Factor; Diet, Sodium-Restricted; Homeostasis; Humans; Hypertension; Nephrotic Syndrome; Oxidative Stress; Renal Insufficiency, Chronic; Renin-Angiotensin System; Skin; Sodium; Sympathetic Nervous System; Vasopressins
PubMed ID
29031360
Volume
24
Issue
5
First Page
325
Last Page
331
