Title

Abnormal corpus callosum induced by diabetes impairs sensorimotor connectivity in patients after acute stroke.

Document Type

Article

Publication Date

1-1-2019

Publication Title

European radiology

Abstract

OBJECTIVES: To test the hypothesis that abnormal corpus callosum (CC) induced by diabetes may impair inter-hemispheric sensorimotor functional connectivity (FC) that is associated with poor clinical outcome after stroke.

METHODS: Forty-five patients with acute ischaemic stroke in the middle cerebral artery territory and 14 normal controls participated in the study. CC was divided into five subregions on three-dimensional T1-weighted image. The microstructural integrity of each subregion of CC was analysed by DTI and the inter-hemispheric FCs in primary motor cortex (M1-M1 FC) and primary sensory cortex (S1-S1 FC) were examined by resting-state functional magnetic resonance imaging.

RESULTS: Diabetic patients (n = 26) had significantly lower fractional anisotropy (FA) in the isthmus of CC (CC

CONCLUSIONS: CC degeneration induced by diabetes impairs sensorimotor connectivity and dysfunction of motor connectivity can contribute to poor recovery after stroke in patients with diabetes.

KEY POINTS: • Abnormal isthmus of corpus callosum in stroke patients with diabetes. • Abnormal isthmus of corpus callosum correlated with decreased inter-hemispheric sensorimotor connectivity. • Decreased motor connectivity correlated with poor stroke outcome in diabetic patients.

Medical Subject Headings

Acute Disease; Aged; Brain Ischemia; Corpus Callosum; Diabetes Complications; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nervous System Diseases

PubMed ID

29926208

Volume

29

Issue

1

First Page

115

Last Page

123

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