Abnormal corpus callosum induced by diabetes impairs sensorimotor connectivity in patients after acute stroke
Yu X, Jiaerken Y, Xu X, Jackson A, Huang P, Yang L, Yuan L, Lou M, Jiang Q, and Zhang M. Abnormal corpus callosum induced by diabetes impairs sensorimotor connectivity in patients after acute stroke. Eur Radiol 2019; 29(1):115-123.
OBJECTIVES: To test the hypothesis that abnormal corpus callosum (CC) induced by diabetes may impair inter-hemispheric sensorimotor functional connectivity (FC) that is associated with poor clinical outcome after stroke.
METHODS: Forty-five patients with acute ischaemic stroke in the middle cerebral artery territory and 14 normal controls participated in the study. CC was divided into five subregions on three-dimensional T1-weighted image. The microstructural integrity of each subregion of CC was analysed by DTI and the inter-hemispheric FCs in primary motor cortex (M1-M1 FC) and primary sensory cortex (S1-S1 FC) were examined by resting-state functional magnetic resonance imaging.
RESULTS: Diabetic patients (n = 26) had significantly lower fractional anisotropy (FA) in the isthmus of CC (CC
CONCLUSIONS: CC degeneration induced by diabetes impairs sensorimotor connectivity and dysfunction of motor connectivity can contribute to poor recovery after stroke in patients with diabetes.
KEY POINTS: • Abnormal isthmus of corpus callosum in stroke patients with diabetes. • Abnormal isthmus of corpus callosum correlated with decreased inter-hemispheric sensorimotor connectivity. • Decreased motor connectivity correlated with poor stroke outcome in diabetic patients.
Medical Subject Headings
Acute Disease; Aged; Brain Ischemia; Corpus Callosum; Diabetes Complications; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nervous System Diseases