Role of microRNA-126 in vascular cognitive impairment in mice

Authors

Peng Yu, Henry Ford Health
Poornima Venkat, Henry Ford HealthFollow
Michael Chopp, Henry Ford HealthFollow
Alex Zacharek, Henry Ford HealthFollow
Yi Shen, Henry Ford HealthFollow
Ruizhuo Ning, Henry Ford Health
Linlin Liang, Henry Ford Health
Wei Li, Henry Ford HealthFollow
Li Zhang, Henry Ford HealthFollow
Julie Landschoot-Ward, Henry Ford HealthFollow
RongCai Jiang
Jieli Chen, Henry Ford HealthFollow

Recommended Citation

Yu P, Venkat P, Chopp M, Zacharek A, Shen Y, Ning R, Liang L, Li W, Zhang L, Landschoot-Ward J, Jiang R, and Chen J. Role of microRNA-126 in vascular cognitive impairment in mice. J Cereb Blood Flow Metab 2019; 39(12):2497-2511.

Document Type

Article

Publication Date

12-1-2019

Publication Title

Journal of cerebral blood flow and metabolism

Abstract

Vascular dementia (VaD) affects cognition and memory. MicroRNA-126 (miR-126) is an angiogenic microRNA that regulates vascular function. In this study, we employ a multiple microinfarction (MMI) model to induce VaD in mice, and investigate VaD-induced cognitive dysfunction, white matter (WM) damage, glymphatic dysfunction and the role of miR-126 in mediating these effects. Male six-to eight-months old C57/BL6 mice (WT) were subject to MMI model, and cerebral blood flow (CBF), vessel patency, glymphatic function, cognitive function, and serum miR-126 expression were measured. Mice were sacrificed at 28 days after MMI. To investigate the role of miR-126 in VaD, cognitive function, water channel integrity and glymphatic function were assessed in male, six-to eight months old conditional-knockout endothelial cell miR-126 (miR-126

PubMed ID

30215264

Volume

39

Issue

12

First Page

2497

Last Page

2511