miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice

Authors

Lei Wang, Henry Ford HealthFollow
Michael Chopp, Henry Ford HealthFollow
Xuerong Lu, Henry Ford HealthFollow
Alexandra Szalad, Henry Ford HealthFollow
Long-Fei Jia, Henry Ford Health
Xian-Shuang Liu, Henry Ford HealthFollow
Kuan-Han Wu, Henry Ford HealthFollow
Mei Lu, Henry Ford HealthFollow
Zhenggang Zhang, Henry Ford HealthFollow

Recommended Citation

Wang L, Chopp M, Lu X, Szalad A, Jia L, Liu XS, Wu KH, Lu M, and Zhang ZG. Mir-146a mediates thymosin beta4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-ii diabetic mice. Brain Res 2019; 1707:198-207.

Document Type

Article

Publication Date

3-15-2019

Publication Title

Brain research

Abstract

Diabetes induces neurovascular dysfunction leading to peripheral neuropathy. MicroRNAs (miRNAs) affect many biological processes and the development of diabetic peripheral neuropathy. In the present study, we investigated whether thymosin-β4 (Tβ4) ameliorates diabetic peripheral neuropathy and whether miR-146a mediates the effect of Tβ4 on improved neurovascular function. Male Type II diabetic BKS. Cg-m+/+Lepr

PubMed ID

30500399

Volume

1707

First Page

198

Last Page

207