miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice.
Wang L, Chopp M, Lu X, Szalad A, Jia L, Liu XS, Wu KH, Lu M, and Zhang ZG. Mir-146a mediates thymosin beta4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-ii diabetic mice. Brain Res 2019; 1707:198-207.
Diabetes induces neurovascular dysfunction leading to peripheral neuropathy. MicroRNAs (miRNAs) affect many biological processes and the development of diabetic peripheral neuropathy. In the present study, we investigated whether thymosin-β4 (Tβ4) ameliorates diabetic peripheral neuropathy and whether miR-146a mediates the effect of Tβ4 on improved neurovascular function. Male Type II diabetic BKS. Cg-m+/+Lepr