Microbleed Prevalence and Burden in Anticoagulant-Associated Intracerebral Bleed

Authors

V A. Lioutas
N Goyal
A H. Katsanos
C Krogias
R Zand
V K. Sharma
Panayiotis N. Varelas, Henry Ford HealthFollow
K Malhotra
M Paciaroni
A Sharaf
J Chang
O Kargiotis
A Pandhi
C Schroeder
A Tsantes
E Boviatsis
C Mehta
Panayiotis Mitsias, Henry Ford HealthFollow
M H. Selim
A V. Alexandrov
G Tsivgoulis

Recommended Citation

Lioutas VA, Goyal N, Katsanos AH, Krogias C, Zand R, Sharma VK, Varelas P, Malhotra K, Paciaroni M, Sharaf A, Chang J, Kargiotis O, Pandhi A, Schroeder C, Tsantes A, Boviatsis E, Mehta C, Mitsias PD, Selim MH, Alexandrov AV, and Tsivgoulis G. Microbleed Prevalence and Burden in Anticoagulant-Associated Intracerebral Bleed. Ann Clin Transl Neurol 2019.

Document Type

Article

Publication Date

7-2019

Publication Title

Ann Clin Transl Neurol

Abstract

Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1–3) vs. 7(4–11); P < 0.001]; ≥5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01–0.83; P = 0.034).

PubMed ID

31402613

ePublication

ePub ahead of print