Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury

Authors

T L. Moore
B GE Bowley
M A. Pessina
S M. Calderazzo
M Medalla
V Go
Zhenggang Zhang, Henry Ford HealthFollow
Michael Chopp, Henry Ford HealthFollow
S Finklestein
A G. Harbaugh
D L. Rosene
Benjamin Buller, Henry Ford HealthFollow

Recommended Citation

Moore TL, Bowley BGE, Pessina MA, Calderazzo SM, Medalla M, Go V, Zhang ZG, Chopp M, Finklestein S, Harbaugh AG, Rosene DL, and Buller B. Mesenchymal Derived Exosomes Enhance Recovery of Motor Function in a Monkey Model of Cortical Injury. Restor Neurol Neurosci 2019; 37(4):347-362.

Document Type

Article

Publication Date

1-1-2019

Publication Title

Restorative neurology and neuroscience

Abstract

BACKGROUND: Exosomes from mesenchymal stromal cells (MSCs) are endosome-derived vesicles that have been shown to enhance functional recovery in rodent models of stroke.

OBJECTIVE: Building on these findings, we tested exosomes as a treatment in monkeys with cortical injury.

METHODS: After being trained on a task of fine motor function of the hand, monkeys received a cortical injury to the hand representation in primary motor cortex. Twenty-four hours later and again 14 days after injury, monkeys received exosomes or vehicle control. Recovery of motor function was followed for 12 weeks.

RESULTS: Compared to monkeys that received vehicle, exosome treated monkeys returned to pre-operative grasp patterns and latency to retrieve a food reward in the first three-five weeks of recovery.

CONCLUSIONS: These results provide evidence that in monkeys exosomes delivered after cortical injury enhance recovery of motor function.

PubMed ID

31282441

Volume

37

Issue

4

First Page

347

Last Page

362