Title

Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury.

Document Type

Article

Publication Date

1-1-2019

Publication Title

Restorative neurology and neuroscience

Abstract

BACKGROUND: Exosomes from mesenchymal stromal cells (MSCs) are endosome-derived vesicles that have been shown to enhance functional recovery in rodent models of stroke.

OBJECTIVE: Building on these findings, we tested exosomes as a treatment in monkeys with cortical injury.

METHODS: After being trained on a task of fine motor function of the hand, monkeys received a cortical injury to the hand representation in primary motor cortex. Twenty-four hours later and again 14 days after injury, monkeys received exosomes or vehicle control. Recovery of motor function was followed for 12 weeks.

RESULTS: Compared to monkeys that received vehicle, exosome treated monkeys returned to pre-operative grasp patterns and latency to retrieve a food reward in the first three-five weeks of recovery.

CONCLUSIONS: These results provide evidence that in monkeys exosomes delivered after cortical injury enhance recovery of motor function.

PubMed ID

31282441

Volume

37

Issue

4

First Page

347

Last Page

362

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