MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke

Authors

Jieli Chen, Henry Ford HealthFollow
Chengcheng Cui, Henry Ford Health
Xiaoping Yang, Henry Ford HealthFollow
Jiang Xu, Henry Ford HealthFollow
Poornima Venkat, Henry Ford HealthFollow
Alex Zacharek, Henry Ford HealthFollow
Peng Yu, Henry Ford Health
Michael Chopp, Henry Ford HealthFollow

Recommended Citation

Chen J, Cui C, Yang X, Xu J, Venkat P, Zacharek A, Yu P, and Chopp M. Mir-126 affects brain-heart interaction after cerebral ischemic stroke. Transl Stroke Res 2017; 8(4):374-385.

Document Type

Article

Publication Date

8-1-2017

Publication Title

Transl Stroke Res

Abstract

Cardiovascular diseases are approximately three times higher in patients with neurological deficits than in patients without neurological deficits. MicroRNA-126 (MiR-126) facilitates vascular remodeling and decreases fibrosis and is emerging as an important factor in the pathogenesis of cardiovascular diseases and cerebral stroke. In this study, we tested the hypothesis that decreased miR-126 after ischemic stroke may play an important role in regulating cardiac function. Wild-type (WT), specific conditional-knockout endothelial cell miR-126 (miR-126

Medical Subject Headings

Actins; Animals; Animals, Newborn; Brain; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Heart Diseases; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Myocardium; Myocytes, Cardiac; NADPH Oxidase 2; Transforming Growth Factor beta; Vascular Cell Adhesion Molecule-1

PubMed ID

28101763

Volume

8

Issue

4

First Page

374

Last Page

385