Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review
Recommended Citation
Girotra T, Mahajan A, and Sidiropoulos C. Levodopa responsive Parkinsonism in patients with hemochromatosis: Case presentation and literature review. Case Rep Neurol Med 2017; 2017:5146723.
Document Type
Article
Publication Date
1-1-2017
Publication Title
Case Rep Neurol Med
Abstract
Hemochromatosis is an autosomal recessive disorder which leads to abnormal iron deposition in the parenchyma of multiple organs causing tissue damage. Accumulation of iron in the brain has been postulated to be associated with several neurodegenerative diseases including Parkinson's disease. The excess iron promotes Parkin and α-synuclein aggregation in the neurons. Excess iron has also been noted in substantia nigra on MRI especially using susceptibility weighted imaging in patients with Parkinson's disease. We present a case of a young male with alleles for both C282Y and H63D who presented with signs of Parkinsonism and demonstrated significant improvement with levodopa treatment.
PubMed ID
28424751
Volume
2017
First Page
5146723
