Targeting Glioma with a Dual Mode Optical and Paramagnetic Nanoprobe across the Blood-brain Tumor Barrier

Authors

Kishor Karki, Henry Ford Health
James R. Ewing, Henry Ford HealthFollow
Meser M. Ali, Henry Ford HealthFollow

Recommended Citation

Karki K, Ewing JR, and Ali MM. Targeting glioma with a dual mode optical and paramagnetic nanoprobe across the blood-brain tumor barrier. J Nanomed Nanotechnol 2016; 7(4).

Document Type

Article

Publication Date

8-1-2016

Publication Title

J Nanomed Nanotechnol

Abstract

In brain tumors, delivering nanoparticles across the blood-tumor barrier presents major hurdles. A clinically relevant MRI contrast agent, GdDOTA and a near-infrared (NIR) fluorescent dye, DL680 were conjugated to a G5 PAMAM dendrimer, thus producing a dual-mode MRI and NIR imaging agent. Systemic delivery of the subsequent nano-sized agent demonstrated glioma-specific accumulation, probably due to the enhanced permeability and retention effect.

PubMed ID

27695645

Volume

7

Issue

4