Models and mechanisms of vascular dementia

Document Type

Article

Publication Date

10-1-2015

Publication Title

Experimental neurology

Abstract

Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease (AD) plaguing the elderly population. VaD is a progressive disease caused by reduced blood flow to the brain, and it affects cognitive abilities especially executive functioning. VaD is poorly understood and lacks suitable animal models, which constrain the progress on understanding the basis of the disease and developing treatments. This review article discusses VaD, its risk factors, induced cognitive disability, various animal (rodent) models of VaD, pathology, and mechanisms of VaD and treatment options.

Medical Subject Headings

Alzheimer Disease; Animals; Cognition Disorders; Dementia, Vascular; Disease Models, Animal; Disease Progression; Humans; Hypertension; Metabolic Diseases; Risk Factors

PubMed ID

25987538

Volume

272

First Page

97

Last Page

108

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