Brainstem Glioblastoma Multiforme in a Patient with NF1

Authors

John T. Fortunato, Henry Ford Health
Brian Reys
Pawan Singh
Edward Pan

Recommended Citation

Fortunato JT, Reys B, Singh P, and Pan E. Brainstem glioblastoma multiforme in a patient with nf1. Anticancer Res 2018; 38(8):4897-4900.

Document Type

Article

Publication Date

8-1-2018

Publication Title

Anticancer research

Abstract

This case report presents the first known case of a brainstem glioblastoma multiforme (GBM) in a patient with neurofibromatosis type 1 (NF1). While research has proposed that larger germ-line mutations in NF1 may be the driving factor that predisposes patients with NF1 to high-grade astrocytomas, this patient had a nonsense mutation in the NF1 gene, suggesting a variant tumorigenesis. Limited data on targeted immunotherapy for NF1 patients with a GBM have been reported and more data are required before targeted therapies could be proven as second-line treatment options.

Medical Subject Headings

Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Stem; Brain Stem Neoplasms; Chemoradiotherapy; Codon, Nonsense; Dacarbazine; Glioblastoma; Humans; Male; Neurofibromin 1; Temozolomide; Young Adult

PubMed ID

30061266

Volume

38

Issue

8

First Page

4897

Last Page

4900