Brainstem Glioblastoma Multiforme in a Patient with NF1
Recommended Citation
Fortunato JT, Reys B, Singh P, and Pan E. Brainstem glioblastoma multiforme in a patient with nf1. Anticancer Res 2018; 38(8):4897-4900.
Document Type
Article
Publication Date
8-1-2018
Publication Title
Anticancer research
Keywords
Adult, Antineoplastic Agents, Alkylating, Astrocytoma, Brain Stem, Brain Stem Neoplasms, Chemoradiotherapy, Codon, Nonsense, Dacarbazine, Glioblastoma, Humans, Male, Neurofibromin 1, Temozolomide, Young Adult
Abstract
This case report presents the first known case of a brainstem glioblastoma multiforme (GBM) in a patient with neurofibromatosis type 1 (NF1). While research has proposed that larger germ-line mutations in NF1 may be the driving factor that predisposes patients with NF1 to high-grade astrocytomas, this patient had a nonsense mutation in the NF1 gene, suggesting a variant tumorigenesis. Limited data on targeted immunotherapy for NF1 patients with a GBM have been reported and more data are required before targeted therapies could be proven as second-line treatment options.
Medical Subject Headings
Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Stem; Brain Stem Neoplasms; Chemoradiotherapy; Codon, Nonsense; Dacarbazine; Glioblastoma; Humans; Male; Neurofibromin 1; Temozolomide; Young Adult
PubMed ID
30061266
Volume
38
Issue
8
First Page
4897
Last Page
4900
