Brainstem Glioblastoma Multiforme in a Patient with NF1.
Fortunato JT, Reys B, Singh P, and Pan E. Brainstem glioblastoma multiforme in a patient with nf1. Anticancer Res 2018; 38(8):4897-4900.
This case report presents the first known case of a brainstem glioblastoma multiforme (GBM) in a patient with neurofibromatosis type 1 (NF1). While research has proposed that larger germ-line mutations in NF1 may be the driving factor that predisposes patients with NF1 to high-grade astrocytomas, this patient had a nonsense mutation in the NF1 gene, suggesting a variant tumorigenesis. Limited data on targeted immunotherapy for NF1 patients with a GBM have been reported and more data are required before targeted therapies could be proven as second-line treatment options.
Medical Subject Headings
Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Stem; Brain Stem Neoplasms; Chemoradiotherapy; Codon, Nonsense; Dacarbazine; Glioblastoma; Humans; Male; Neurofibromin 1; Temozolomide; Young Adult