Neuroimmunology in ageing and longevity: a special collection issue of Biogerontology

Document Type

Article

Publication Date

7-9-2025

Publication Title

Biogerontology

Abstract

Ageing is associated with neuroimmune shifts from a resting to a hyperactive and inflammatory state, termed 'Neuroinflammageing', attributed to microglial priming, hyperactive astrocytes, cytokine and chemokine release, blood brain barrier leakage, and infiltration of peripheral immune cells. This special issue of Biogerontology on 'Neuroimmunology in Ageing and Longevity' brings together 11 reviews and original research papers dealing with the complex cross-talk between CNS and peripheral immune cells and molecules in the context of ageing. The articles compiled under this issue further address how understanding neuroimmune pathways may help to identify targets to design interventional regimens for healthy brain ageing and longevity.

Medical Subject Headings

Humans; Longevity; Aging; Neuroimmunomodulation; Animals

PubMed ID

40632153

Volume

26

Issue

4

First Page

141

Last Page

141

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