Functional Neuroanatomy of Secondary Self-Injurious Behavior
Recommended Citation
Peeters S, Skoch J, Holt H, Mubita L, Choudhary EA, Vadivelu KP, Gilbert DL, Wu SW, Keebaugh AC, Air E, and Vadivelu S. Functional neuroanatomy of secondary self-injurious behavior. Pediatr Neurosurg 2018; 53(2):71-80.
Document Type
Article
Publication Date
1-1-2018
Publication Title
Pediatric neurosurgery
Abstract
BACKGROUND: Secondary self-injurious behavior (SSIB) is underreported and predominantly not associated with suicide. In both adults and children, SSIB can cause intractable self-harm and is associated with a variety of clinical disorders, particularly those involving dysfunctional motor control.
METHODS: We performed a literature review evaluating the clinical efficacy of deep-brain stimulation (DBS) as modulating SSIB observations and review current progress in preclinical SSIB animal studies.
RESULTS: Neuromodulation is an effective therapeutic option for several movement disorders. Interestingly, this approach is emerging as a potentially effective treatment for movement disorder-associated SSIB (secondary); however, it is important to understand the neuroanatomy, clinical appraisal, and outcome data when considering surgical therapy for SSIB.
CONCLUSION: The current review examines the literature encompassing animal models and human case studies while identifying existing hypotheses from cytoarchitectonic-based targeting to neurotransmitter-based pathways. This review also highlights the need for awareness of an underrecognized pathology that may be amenable to DBS.
Medical Subject Headings
Animals; Basal Ganglia; Brain; Deep Brain Stimulation; Humans; Mental Disorders; Movement Disorders; Neuroanatomy; Pediatrics; Self-Injurious Behavior
PubMed ID
29402877
Volume
53
Issue
2
First Page
71
Last Page
80
