Quantification of pial collateral pressure in acute large vessel occlusion stroke: basic concept with patient outcomes

Authors

Rizwan A. Tahir, Henry Ford HealthFollow
Muhammad Affan, Henry Ford HealthFollow
Horia Marin, Henry Ford HealthFollow
Sameah A. Haider, Henry Ford HealthFollow
Owais K. Alsrouji, Henry Ford HealthFollow
Ayesha Ahmad, Henry Ford HealthFollow
Alex B. Chebl, Henry Ford HealthFollow
Angelos Katramados, Henry Ford HealthFollow
Meredith Van Harn, Henry Ford HealthFollow
Max Kole, Henry Ford HealthFollow

Recommended Citation

Tahir RA, Affan M, Marin H, Haider SA, Alsrouji OK, Ahmad A, Chebl AB, Katramados A, Van Harn M, and Kole M. Quantification of pial collateral pressure in acute large vessel occlusion stroke: basic concept with patient outcomes. Neuroradiology 2021.

Document Type

Article

Publication Date

1-28-2021

Publication Title

Neuroradiology

Abstract

PURPOSE: Pial collateral perfusion to the ischemic penumbra plays a critical role in determining patient outcomes in acute stroke. We aimed to assess the validity and reliability of an intra-procedural technique for measuring and quantifying the pial collateral pressure (QPCP) to ischemic brain tissue during acute stroke secondary to LVO. QPCP measurements were correlated with standard computed tomography angiography (CTA) and digital subtraction angiography imaging assessments of pial collateral perfusion and outcomes after mechanical endovascular revascularization (MER).

METHODS: This prospective cohort study included 60 consecutive patients with middle cerebral artery (MCA)-M1 and proximal M2 occlusions. QPCP measurements were obtained during MER. The validity of QPCP measurements was evaluated using four widely accepted collateral grading scales. QPCP measurements were also analyzed as a predictor of patient outcomes utilizing National Institute of Health Stroke Scale reduction at 24 h and modified Rankin Scale (mRS) scores at 30 days.

RESULTS: QPCP measurements and QPCP ratio (QPCP/systemic mean arterial blood pressure) showed a statistically significant association with single-phase pretreatment CTA Maas and American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology binary grading scales. Patient outcomes demonstrated for every 10-unit increase in QPCP, the odds of mRS 0-2 at 30 days increased by 76% (p = 0.019).

CONCLUSION: QPCP measurements related best with the pretreatment CTA Maas collateral grading scale but were more strongly associated with patient outcomes than any of the four widely accepted collateral grading scales. Greater QPCP was significantly associated with better overall patient outcomes as defined by mRS at 30 days.

PubMed ID

33507337

ePublication

ePub ahead of print