When the methylome becomes the microscope
Recommended Citation
Noushmehr H. When the methylome becomes the microscope. Cancer Cell 2025;44(2):251-253.
Document Type
Article
Publication Date
2-9-2026
Publication Title
Cancer cell
Keywords
Humans, DNA Methylation, Epigenome, Neoplasms, Prognosis, Central Nervous System Neoplasms
Abstract
DNA methylation patterns stratify tumors into distinct biological, prognostic, and therapeutic response features. In this issue of Cancer Cell, Sill et al. expand the Heidelberg CNS Tumor Methylation Classifier from 91 to 184 subclasses using 7,495 methylomes, enhancing diagnostic accuracy, revealing new tumor types, and making methylation-based classification more widely accessible.
Medical Subject Headings
Humans; DNA Methylation; Epigenome; Neoplasms; Prognosis; Central Nervous System Neoplasms
PubMed ID
41478274
ePublication
ePub ahead of print
Volume
44
Issue
2
First Page
251
Last Page
253
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