The Multifaceted Role of microRNA-10b (miR-10b) in Glioblastoma: From Oncogenic Driver to Therapeutic Target
Recommended Citation
Chen M, Medarova Z, Rogers LR, Moore A. The Multifaceted Role of microRNA-10b (miR-10b) in Glioblastoma: From Oncogenic Driver to Therapeutic Target. Cells. 2026;15(9).
Document Type
Article
Publication Date
4-26-2026
Publication Title
Cells
Keywords
Humans, MicroRNAs, Glioblastoma, Brain Neoplasms, Animals, Gene Expression Regulation, Neoplastic, Oncogenes, Tumor Microenvironment, Oligonucleotides, Antisense, Carcinogenesis
Abstract
Glioblastoma (GBM) remains one of the most lethal and treatment-resistant human malignancies, characterized by extreme molecular heterogeneity and a highly immunosuppressive tumor microenvironment (TME). MicroRNAs are a set of small endogenous non-coding RNA molecules which play critical roles in various biological processes including carcinogenesis. Recent evidence identifies microRNA-10b (miR-10b) as a regulator of gliomagenesis, with glioblastoma exhibiting a unique state of "oncogene addiction" to this molecule. This review summarizes current research on the mechanistic roles of miR-10b in GBM tumor progression and immune evasion, evaluates innovative antisense oligonucleotide delivery systems, and explores the clinical potential of combining miR-10b inhibition with standard-of-care treatments.
Medical Subject Headings
Humans; MicroRNAs; Glioblastoma; Brain Neoplasms; Animals; Gene Expression Regulation, Neoplastic; Oncogenes; Tumor Microenvironment; Oligonucleotides, Antisense; Carcinogenesis
PubMed ID
42121885
Volume
15
Issue
9
