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Submissions from 2019

Systematic Approaches to Predict Oncogenic Transcriptional Regulatory Circuitries Identify Important Nodes in High-Grade Serous Ovarian Cancer, B J. Abraham, J Reddy, M A. Fonseca, I A. Klein, L K. Afeyan, R I. Corona, P Cejas, F Segato, B Y. Karlan, S A. Gayther, M L. Freedman, Houtan Noushmehr, M Brown, U A. Matulonis, K Lawrenson, and R A. Young

Does non-automated phone call notification improve no-show rates in neurology resident clinic?, Abdullah Alshammaa, K Shah, S Madani, Muhammad Affan, S Zahoor, N Baki, A Yousuf, Lonni Schultz, Iram Zaman, and Tobias Walbert

Decreasing morbidity with nasal cerebrospinal fluid leak repair: No fat or fascia and no nasal packing, Karam Asmaro, John R Craig, and Jack Rock

DNA methylome profiling of invasive pituitary macroadenomas reveals deregulation in enhancer regions involved in pituitary morphogenesis and developmental pathways, Karam Asmaro, M S. Mosella, Thais S Sabedot, T Malta, M Felicella, Todd Aho, T Poisson, Ana C de Carvalho, Houtan Noushmehr, Jack Rock, and Ana V Castro

Non-Invasive Prediction of Glioma Tumor Stemness Using Multimodal MRI, Esmaeil Davoodi-Bojd, T Malta, Brent Griffith, James Snyder, Tobias Walbert, Houtan Noushmehr, and Hamid Soltanian-Zadeh

Design and implementation of a quality improvement registry for DBS in Parkinson's disease, J Jimenez-Shahed, P F. D'Haese, J Kirk, M York, A Berg, L Shih, Jason M. Schwalb, and J McInerney

Overall Survival Prediction in Glioblastoma Using Clinical Factors Combined with Texture Features Extracted from 3D Convolutional Neural Networks, Joon K Lee, WeiWei Zong, Zhenzhen Dai, Chang Liu, James Snyder, and Ning Winston Wen

Updated phase I trial of anti-LAG-3 or anti-CD137 alone and in combination with anti-PD-1 in patients with recurrent GBM, M Lim, X Ye, A F. Piotrowski, A S. Desai, M S. Ahluwalia, Tobias Walbert, J D. Fisher, S Desideri, Z Belcaid, C Jackson, L B. Nabors, P Y. Wen, and S A. Grossman

Drivers of Episode Payments for Non-Cervical Spinal Fusion, Mohamed Macki, J D. Syrjamaki, S E. Regenbogen, Victor Chang, and David R. Nerenz

The Effect of Physical Therapy on Time to Discharge After Lumbar Interbody Fusion, Mohamed Macki, Hesham M. Zakaria, Lara W. Massie, B Dakroub, and Victor Chang

Meningioma Subgroups Associated with Functional Genomic Elements Defined by DNA Methylation, T M. Malta, James Snyder, Michael Wells, Ana C. de Carvalho, Laila M. Poisson, C Souza, G Zadeh, K Aldape, D Tirapelli, C Carlotti, Y Lee, Steven N. Kalkanis, Tobias Walbert, and Houtan Noushmehr

Design and Implementation of a Quality Improvement Registry for Deep Brain Stimulation in Parkinson's Disease, J McInerney, Jason M. Schwalb, P F. D'Haese, J Kirk, M York, A Berg, L Shih, and J Jimenez-Shahed

Randomized Prospective Trial of Stereotactic Radiosurgery versus Chemotherapy for Recurrent Malignant Glioma After Second-line Chemotherapy, Ankit Modh, David Bergman, R Hanna, Lonni R. Schultz, James Snyder, Tom Mikkelsen, Benjamin Movsas, S Ryu, and M Salim Siddiqui

Recurrent Thrombectomy in Patients with Prior Mechanical Endovascular Revascularization: A Single Center Experience, G A. Mohamed, K Arshad, Muhammad Affan, Owais Alsrouji, Daniel J. Miller, Max Kole, and Horia Marin

Increased Glioma Collagen Is Associated with Greater Blood Flow and Peri-Tumoral Fluid Flux, but Less Infiltration, Tavarekere N. Nagaraja, R Elmghirbi, Stephen L. Brown, Ian Y. Lee, Glauber Cabral, Swayamprava Panda, Robert A. Knight, and James R. Ewing

Noninvasive Estimation of Tumor Interstitial Fluid Pressure by DCE-MRI and Its Confirmation by Invasive Wick-In-Needle Technique in a Rat Glioblastoma Model, Tavarekere N. Nagaraja, R Elmghirbi, Stephen L. Brown, Swayamprava Panda, Glauber Cabral, Ian Y. Lee, Robert A. Knight, and James R. Ewing

Development and validation of an individualized predictor of meningioma recurrence: A multicenter retrospective cohort study, F Nassiri, Y Mamatjan, S Suppiah, J Badhiwala, S Mansouri, S Karimi, Laila M. Poisson, Houtan Noushmehr, P Harter, P Baumgarten, M Weller, M Preusser, C Herold-Mende, F Sahm, A Von Deimling, K Aldape, and G Zadeh

Pre-Surgical Identification of Diagnostic, Prognostic and Predictive DNA Methylation-Based Markers in Serum (Liquid Biopsy) of Patients Harboring Gliomas, Houtan Noushmehr, Thais S. Sabedot, T M. Malta, Kevin K. Nelson, James Snyder, Michael Wells, M S. Mosella, Ana C. de Carvalho, Karam Asmaro, Lisa Scarpace, Adam Robin, M L. Rosenblum, Tom Mikkelsen, Jack Rock, Tobias Walbert, Ian Y. Lee, Laila M. Poisson, Steven N. Kalkanis, and Ana V. Castro

The Influence of Cellular Developmental State on Response to Therapeutics in Glioblastoma, Oluwademilade Nuga, Ana C. de Carvalho, D Ruden, Stephen L. Brown, Indrani Datta, and T Malta

Bioinformatic Method to Define Epigenetically Regulated Enhancer Elements Associated with Cancer, Thais S. Sabedot, S H. Cassel, G F. Gao, C A. Lareau, A Cherniack, A Lazar, C Kadoch, and Houtan Noushmehr

Using a Quality Improvement Framework to Examine Deep Brain Stimulation in Parkinson's Disease: The RAD-PD Initiative, J J. Shahed, P F. D'Haese, J Kirk, M York, A Berg, L Shih, Jason M. Schwalb, and J McInerney

Deep Learning Classification of Neuro-Oncology Medical Documents, Michael Wells, Thais S. Sabedot, T Malta, James Snyder, Laila M. Poisson, and Houtan Noushmehr

A Prospective, Randomized, Blinded, and Placebo-Controlled Study of Cerebrolysin Effect on Long-Term Functional and Histological Outcomes in Rats with Traumatic Brain Injury, Ye Xiong, Yi Zhang, Yanlu Zhang, Zheng Gang Zhang, Li Zhang, Mei Lu, Talan Zhang, and H Wu

Chronicity of Preoperative Opioid Usage Predicts Patient Satisfaction, Return to Work, and Achieving ODI MCID up to Two Years After Lumbar Fusion: Analysis from the Michigan Spine Surgery Improvement Collaborative (MSSIC), Hesham M. Zakaria, Michael Bazydlo, Lonni Schultz, J G. Khalil, J M. Schwalb, P Park, and Victor Chang

Preoperative PHQ-2 Scoring Predicts Patient Satisfaction and Return to Work up to One-Year After Lumbar Fusion: A Two-Year Analysis from the Michigan Spine Surgery Improvement Collaborative (MSSIC), Hesham M. Zakaria, Michael Bazydlo, Lonni Schultz, J M. Schwalb, P Park, and Victor Chang

Sarcopenia Independently and Accurately Predicts Survival in Patients Undergoing Spine Surgery for Metastatic Tumors: A Multicenter Retrospective Cohort Study, Hesham M. Zakaria, Y S. Saadeh, D Lau, Z Pennington, Brandon Wilkinson, A Ahmed, Mohamed Macki, H Deng, A Chandra, M Abouelleil, J Rick, J Fateh, D Chou, D M. Sciubba, P Park, and Victor Chang

Exosome Treatment Improves Functional Recovery After Traumatic Brain Injury in Rats: A Dose-Response and Therapeutic Window Study, Yi Zhang, Yanlu Zhang, Michael Chopp, Mei Lu, Zheng Gang Zhang, Asim Mahmood, and Ye Xiong

Submissions from 2018

Exosomal miR-29 mediates the therapeutic effects of placenta derived mesenchymal stromal cells in Duchenne muscular dystrophy, P Berenstein, A Bier, D Margoulis, H Goldstein, Simona Cazacu, A Dori, and C Brodie

Heterogeneous extrachromosomal amplification of mutant PDGFRA is associated with an aggressive phenotype in glioblastoma, Artem D. Berezovsky, Andrea D Transou, Susan M Irtenkauf, Laura A Hasselbach, J Koeman, H Kim, R G. Verhaak, Tom Mikkelsen, Laila M Poisson, and Ana C de Carvalho

DNA methylation signature associated with risk of recurrence in papillary thyroid carcinoma, Arti Bhan, M S. Mosella, Michael C. Singer, Christian Keller, Rand Abou Shaar, Steven S. Chang, Vivian Wu, J Stephen, Maria J. Worsham, Laila M. Poisson, Wamidh L. Alkhoory, T Malta, Thais S Sabedot, Houtan Noushmehr, and Ana V Castro

Durable responses observed in recurrent high-grade glioma (rHGG) with Toca 511 and Toca FC treatment, Timothy F Cloughesy, Joseph Landolfi, Michael A Vogelbaum, Derek Ostertag, B Elder, B Carter, C C. Chen, Steven N Kalkanis, Santosh Kesari, A Lai, Ian Lee, L Liau, Tom Mikkelsen, L Nghiemphu, David Piccioni, William Accomando, Oscar R Diago, D Hogan, Douglas J Jolly, K Wood, H Gruber, A Das, and Tobias Walbert

Toca 511 & Toca FC: Evaluation of durable response rate in the post-resection setting and association with survival in patients with recurrent high grade glioma, Timothy F Cloughesy, Joseph Landolfi, Michael A Vogelbaum, Derek Ostertag, B Elder, B Carter, C Chen, Steven N Kalkanis, Santosh Kesari, A Lai, Ian Lee, L Liau, P Nghiemphu, David Piccioni, William Accomando, Oscar R Diago, D Hogan, D Jolly, K Wood, T Kheoh, H Gruber, A Das, and Tobias Walbert

Treatment of recurrent hgg patients with the retroviral replicating vector Toca 511 and Toca FC gives durable responses and survival lasting 3 years or longer: Immune mechanisms and molecular analyses of tumors, A Das, Derek Ostertag, D Hogan, William Accomando, Oscar R Diago, A Haghighi, D Gammon, M Rodriguez-Aguirre, L Mitchell, Steven N Kalkanis, Tom Mikkelsen, Joseph Landolfi, B Carter, C Chen, Michael A Vogelbaum, Timothy F Cloughesy, H Gruber, and D Jolly

Stereotactic radiosurgery for malignant intradural and intramedullary tumors of the spine, Erinma Elibe, David Boyce-Fappiano, Ian Y. Lee, Jack Rock, M Salim Siddiqui, and Farzan Siddiqui

Significance of hormone therapy & bisphosphonate use on vertebral compression fracture (VCF) incidence following spine stereotactic body radiation therapy (SBRT) for breast cancer metastases, Erinma Elibe, David Boyce-Fappiano, Eleanor Walker, Ian Y. Lee, Jack Rock, M Salim Siddiqui, and Farzan Siddiqui

Sex disparities in health and health care utilization after Parkinson diagnosis: Rethinking PD associated disability, M Fullard, D Thibault, V Todaro, S Foster, L Katz, R Morgan, D Kern, Jason M Schwalb, E U. Mendoza, L Shulman, N Dahodwala, and A Willis

Development of 3D printed immobilization for the MR-linac: Toward high precision brain treatments, Carri Glide-Hurst, Eric Myers, D Du, Joshua Kim, Ning Wen, Benjamin Movsas, S Siddiqui, Tobias Walbert, Steven N Kalkanis, and Indrin J. Chetty

RAD-PD: Registry for the advancement of DBS in Parkinson's disease, J Jimenez-Shahed, S Bressman, M Burack, E Farace, J McInerney, J Kirk, R Saunders-Pullman, Jason M Schwalb, L Shih, M Spindler, E Moro, and M York

Quality improvement: improving primary care follow-up for stroke/TIA patients, M S. Khan, Gamaleldin Osman, Abhimanyu Mahajan, Abdullah Alshammaa, Mohammed Kananeh, Reema Butt, and Tobias Walbert

Evidence based management of normal pressure hydrocephalus: Lessons and future directions, Abhimanyu Mahajan, Mohamed Macki, Manpreet Kaur, Marina Novikova, R Shatz, and Jason M Schwalb

Comprehensive analysis of cancer stemness, T M. Malta, A Sokolov, A J. Gentles, T Burzykowski, Laila M Poisson, J Weinstein, B Kaminska, J Huelsken, L Omberg, O Gevaert, A Colaprico, P Czerwinska, S Mazurek, L Mishra, H Heyn, A Krasnitz, AK Godwin, AJ Lazar, JM Stuart, K Hoadley, PW Laird, Houtan Noushmehr, and M Wiznerowicz

Unilateral versus bilateral ventral intermediate nucleus deep brain stimulation for axial essential tremor symptoms, K Mitchell, D Peichel, R Wharen, M Okun, B Guthrie, R Uitti, P Larson, H Walker, R Pahwa, K Dashtipour, J Jankovic, K Foote, Jason M Schwalb, B Ford, R Simpson, F Phibbs, J Neimat, RM Stewart, F Marshall, and J Ostrem

Whole genome DNA is distinctly methylated in functioning and non-functioning pituitary macroadenomas, M S. Mosella, Thais S Sabedot, T M. Malta, Jack Rock, Michelle M Felicella, Todd Aho, Laila M Poisson, Ana C de Carvalho, Houtan Noushmehr, and Ana V Castro

Identification of novel MET fusion transcript amplification in glioblastoma, O Nuga, Ana C de Carvalho, Yuling Meng, Laura A Hasselbach, Kevin K Nelson, Susan M Irtenkauf, and Andrea D Transou

Overexpression of miR-504 in glioma stem cells inhibits the oncogenic potential and the crosstalk of these cells with microglia via exosomal delivery, D Rand, Simona Cazacu, X Hong, Cunli Xiang, Ruicong She, Indrani Datta, Laila M Poisson, and C Brodie

Tumor treating fields (TTFields) on healthrelated quality of life (HRQoL) in ndGBM: An exploratory analysis of the EF-14 phase I-II trial, Tobias Walbert, G Lavy-Shahaf, SA Toms, and S Kesari

Submissions from 2017

Moyamoya vasculopathy in a patient with scleroderma: A case report and review of the literature, Ayesha Ahmad, Rizwan A Tahir, and Panayiotis Mitsias

Nanoformulation of a vascular disrupting agent for the treatment of glioma with MRI monitoring, Meser Ali, S Jayasundara, Ana C de Carvalho, and James R. Ewing

Development and testing of nanoformulation of a vascular disrupting agent in rat glioma with MRI monitoring, Meser Ali, S Jayasundara, and James R. Ewing

The effect of the percutaneous endoscopic gastrostomy (PEG) tube placement on the quality-of-life of ALS patients and their caregivers, Ximena Arcila-Londono, Rabih Kashouty, S Ryczko, Kara Steijlen, Daniel S Newman, and Tobias Walbert

Fluorinated Eu-II-based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging, L A. Basal, M D. Bailey, J Romero, Meser M Ali, L Kurenbekova, J Yustein, R G. Pautler, and M J. Allen

Mesenchymal stem cells and their secreted exosomes exert therapeutic effects in Duchenne muscular dystrophy, A Bier, P Bernstein, Simona Cazacu, A Dori, and Chaya Brodie

Incidence of local and marginal treatment failure following postoperative single fraction spine stereotactic radiosurgery, David Boyce-Fappiano, Erinma Elibe, M S U Siddiqui, Ian Y. Lee, Jack Rock, and Farzan Siddiqui

The novel long non-coding RNA TALNEC2 regulates the stemness and mesenchymal transformation of glioma stem cells and their exosome mediated interaction with microglia cells, S Brodie, Simona Cazacu, Laila M. Poisson, Steven N Kalkanis, D Ginsburg, and Chaya Brodie

Durable responses observed in idh1 wildtype and mutant recurrent high grade glioma (RHGG) with Toca 511 & Toca FC treatment, Timothy Cloughesy, Joseph Landolfi, Michael A Vogelbaum, Derek Ostertag, B Elder, B Carter, C Chen, Steven N. Kalkanis, A Lai, Tom Mikkelsen, P Nghiemphu, David Piccioni, William Accomando, Oscar R Diago, D Hogan, D Jolly, K Wood, L Yang, H Gruber, A Das, and Tobias Walbert

Discordant inheritance of chromosomal and extrachromosomal DNA elements contribute to dynamic disease evolution in glioblastoma, Ana C de Carvalho, H Kim, Laila M. Poisson, J Koeman, Tom Mikkelsen, and R G. Verhaak

Repeat courses of spine stereotactic radiosurgey (SRS): Efficacy and toxicity, Erinma Elibe, David Boyce-Fappiano, S Siddiqui, Ian Y. Lee, Jack Rock, and Farzan Siddiqui

RAD-PD: Registry for the advancement of DBS in Parkinson's disease, J Jimenez-Shahed, S Bressman, M Burack, E Farace, J McInerney, J Kirk, R Saunders-Pullman, Jason Schwalb, L Shih, M Spindler, E Moro, and M York

Long-term follow-up data from 126 patients with recurrent high grade glioma from three phase 1 trials of toca 511 and toca fc: Update and justification for a phase 2/3 trial, D Jolly, Manish K Aghi, Michael A Vogelbaum, Steven N Kalkanis, Daniela A Bota, C C. Chen, B Carter, B Elder, J Engh, S A. Goldlust, G J. Kaptain, S Kesari, J Landolfi, L M. Liau, Tom Mikkelsen, David Piccioni, Jana Portnow, S Singer, Tobias Walbert, H Gruber, C Ibanez, L Mitchell, Derek Ostertag, J S. Shorr, L Q. Yang, A Das, and Timothy Cloughesy

Analysis of hypoplastic variants of the circle of willis in patients with first-ever lacunar stroke, Angelos Katramados, Horia Marin, Maximillian K Kole, Panayiotis N. Varelas, Daniel Miller, Shaneela Malik, Hebah Hefzy, Sumul Modi, Lonni Schultz, K Marmagkiolis, D Tsitlakidou, Muhammad Affan, and Panayiotis Mitsias

Efficacy analysis of ABT-414 with or without temozolomide (TMZ) in patients (pts) with EGFR-amplified, recurrent glioblastoma (rGBM) from a multicenter, international phase I clinical trial, A B. Lassman, M J. Van Den Bent, H K. Gan, D A. Reardon, P Kumthekar, N A. Butowski, Z Lwin, Tom Mikkelsen, L B. Nabors, K P. Papadopoulos, M Penas-Prado, J Simes, H Wheeler, E J. Gomez, H J. Lee, L Roberts-Rapp, H Xiong, E E. Bain, D Maag, and R T. Merrell

PD-l1 expression associated with glioma molecular subtypes: Clinical implications, T M. Malta, James Snyder, Steven N. Kalkanis, Ana V Castro, and Houtan Noushmehr

Molecular hallmarks of cancer: Stemness, T Malta, A Sokolov, A J. Gentles, T Burzykowski, O Gevaert, PW Laird, Houtan Noushmehr, and M Wiznerowicz

Malignant cerebral edema associated with radiation and laser ablation for brain tumors, Stefania Maraka, Karam Asmaro, Tobias Walbert, and Ian Lee

Trends of hospitalization cost of aneurysmal subarachnoid hemorrhage in the United States, Sumul Modi, Kavit Shah, Muhammad Affan, Rizwan A Tahir, Panayiotis N. Varelas, and Horia Marin

Epigenomic glioma subtype evaluation across 31 tumor types, M S. Mosella, T Sarraf, T M. Malta, T Chedraoui, Houtan Noushmehr, and Ana V Castro

Magnetization transfer and T2-weighted MRI studies are useful for visualizing phenotypic presentations of orthotopic, patientderived xenograft mouse models of glioblastoma, Tavarekere N. Nagaraja, Rasha Elmghirbi, Susan M Irtenkauf, Laura A Hasselbach, B Tawil, Stephen L. Brown, Swayamprava Panda, Glauber Cabral, Tom Mikkelsen, James R. Ewing, and Ana C de Carvalho

Raman laser damage threshold of rat pial cortex, Thomas Noh, Michelle Felicella, Laila M Poisson, Hesham Mostafa Zakaria, Ana C de Carvalho, B Broadbent, G Auner, and Steven N Kalkanis

Immunological activation in responding patients with recurrent HGG after treatment with toca 511 & toca FC: Results from a phase 1 trial, Derek Ostertag, William Accomando, D Hogan, Oscar R Diago, D Gammon, A Haghighi, L Mitchell, M Rodriguez-Aquirre, Timothy Cloughesy, Steven N. Kalkanis, Tom Mikkelsen, J Landolfi, C Chen, Michael A Vogelbaum, H Gruber, A Das, and D Jolly

Phase 2 trial of SL-701, a novel immunotherapy comprised of synthetic short peptides against GBM targets IL-13ra2, EPHA2, and survivin, in adults with second-line recurrent GBM, D A. Reardon, B Nabors, P Kumthekar, M Badruddoja, K Fink, F Lieberman, J Hu, E Dunbar, Tobias Walbert, D Schiff, J Sherman, D Tran, L S. Ashby, N Butowski, F Iwamoto, C Moertel, M Schulder, J Chen, J Bullington, S Shemesh, C Brooks, T Goswami, and D M. Peereboom

Depletion of 5-hydroxymethylcytosine in aggressive G-CIMP subtype, Thais S Sabedot, Laila M. Poisson, Ana C de Carvalho, and Houtan Noushmehr

Predictive signature of malignant recurrence in G-CIMP tumors, C F. Souza and Houtan Noushmehr

Quantifiable levels of the transgene, cytosine deaminase, in tumor samples following intravenous delivery of toca 511 in patients with recurrent high grade glioma, Tobias Walbert, D Bota, M Vogelbaum, Steven N Kalkanis, L Liau, Tom Mikkelsen, H Gruber, J S. Shorr, M Rodriguez-Aguirre, Derek Ostertag, L Mitchell, D Jolly, and Timothy Cloughesy

Intravenous delivery of toca 511 in patients with high grade glioma results in quantifiable expression of cytosine deaminase in tumor tissue, Tobias Walbert, D Bota, M Vogelbaum, Steven N. Kalkanis, L Liau, Tom Mikkelsen, H Gruber, J S. Shorr, M Rodriguez-Aquirre, Derek Ostertag, L Mitchell, D Jolly, and Timothy Cloughesy

Deciphering glioma intrinsic transcriptional subtypes identifies tumor evolution associates with changes in immune-microenvironment, QH Wang, BL Hu, X Hu, M Squatrito, Lisa Scarpace, Ana C de Carvalho, S Lyu, PP Li, Y Li, F P. Barthel, HJ Cho, YH Lin, N Satani, E Martinez-Ledesma, S Y. Zheng, E Chang, A Olar, ZD Lan, G Finocchiaro, JJ Phillips, MS Berger, K Gabrusiewicz, GC Wang, E Eskilsson, J Hu, Tom Mikkelsen, R Depinho, F Muller, A Heimberger, E Sullman, DH Nam, and R Verhaak