Whole genome DNA is distinctly methylated in functioning and non-functioning pituitary macroadenomas

Authors

M S. Mosella, Henry Ford Health
Thais S. Sabedot, Henry Ford HealthFollow
T M. Malta, Henry Ford Health
Jack Rock, Henry Ford HealthFollow
Michelle M. Felicella, Henry Ford Health
Todd Aho, Henry Ford HealthFollow
Laila M. Poisson, Henry Ford HealthFollow
Ana C. de Carvalho, Henry Ford HealthFollow
Houtan Noushmehr, Henry Ford HealthFollow
Ana V. Castro, Henry Ford HealthFollow

Recommended Citation

Mosella MS, Sabedot TS, Malta TM, Rock J, Felicella MM, Aho T, Poisson L, De Carvalho A, Noushmehr H, and Castro AVB. Whole genome DNA is distinctly methylated in functioning and non-functioning pituitary macroadenomas. Endocrine Reviews 2018; 39(2).

Document Type

Conference Proceeding

Publication Date

2018

Publication Title

Endocrine Reviews

Abstract

Few somatic mutations or epigenetic alterations were reported to be associated with pituitary adenomas (PA) functional status. In order to evaluate the role of global DNA methylation pattern in Functioning (FPA) and non-functioning PA (NFPA), we profiled the DNA methylome of 14 formalin- fixed paraffin-embedded pituitary specimens (5 non-tumoral, 9 macroadenomas, 6 NFPA; 5 FPA; 5 invasive; 3 large PA, 25±10 mm size) using the Human Illumina EPIC array platform (HM850K). Non-parametric supervised analyses of the methylomes were performed among NFPAs, FPAs and non-tumoral pituitary specimens; differentially methylated probes (DMPs)(p

Volume

39

Issue

2